Patrick Dempsey	Ellen Pompeo
Isaiah Washington (S1-2-3)	Sandra Oh
Katherine Heigl	Justin Chambers
T. R. Knight	Sara Ramirez
Kate Walsh (S1-2-3)	Eric Dane
Chandra Wilson	James Pickens Jr.
Chyler Leigh	Brooke Smith (S4- S5 fino al 5.07)
Kevin McKidd	Jessica Capshaw